Hereditary Cancer Testing
Diagnostic Imaging Specialists of Chicago is partnering with Myriad Genetics to administer the myRisk™ Hereditary Cancer Panel to our Chicago patients.
The myRisk™ 25-gene panel has the ability to capture more mutation carriers than BRACAnalysis and COLARIS combined. This new testing technology can identify elevated risk for eight cancers: breast, endometrial, prostate, melanoma, pancreatic, colorectal, gastric and ovarian. While these genetic tests do not measure if the patient has one of these cancers, they are used to determine the patient’s risk for developing these hereditary cancers compared to those without the genetic mutation.
Who should get a myRisk™ genetic test?
The National Comprehensive Cancer Network provides the following guidelines for screening if the patient or their family members have any of the following:
- Breast Cancer, Colorectal Cancer or Endometrial cancer diagnosed before the age 50
- Several close blood relatives that have the same type of cancer
- Ex: a father, daughter and sisters with breast cancer
- A combination of cancers on the same side of the family, such as 2 or more members have had:
- Breast, ovarian, prostate and pancreatic cancers
- Colorectal, endometrial, ovarian, gastric, pancreatic and other cancers
- Melanoma and pancreatic
- Have been diagnosed at any age with:
- Ovarian Cancer
- Male Breast Cancer
- “Triple Negative” Breast Cancer
- Colorectal cancer with an abnormal MSI/IHC, or MSI associated histology
- Endometrial Cancer with an abnormal MSI/IHC
- 10 or more Colorectal polyps
Are you eligible for myRisk™ genetic cancer test?
Recommendations for patient testing are based on your personal or family history of different types of cancer. If cancer is common in your family and you are concerned about your genetic risk for the mutation, then you can fill out the Risk Assessment form or take the Myriad hereditary cancer quiz.
The cancer quiz calculates risk by looking at your own cancer history and the history of first and second degree family members with cancer, their age, family members known to have the gene mutation, etc.
You are welcome to fill out the Risk Assessment form online and submit it to our email to inquire about your eligibility for the gene mutation test.
How is the myRisk™ test completed?
The test is very simple and only takes a few minutes to complete. A sample of the patient's saliva or blood is obtained and sent to Myriad Genetic Laboratories for analysis. Test results are delivered to our physician within roughly three to four weeks. The patient will be asked to return to our office to discuss the results and next steps.
myRisk™ test results
There are three options for test results: Positive, Negative, or Variant.
What are the risks associated with hereditary gene mutations?
Harmful genetic mutations can increase a person’s chance of developing cancer. These inherited mutations are thought to play a role in about 5-10% of all cancers.
However, because each case depends on the person and their surroundings, not all patients that have inherited a genetic mutation will develop cancer. Some people might not show effects of these mutations (incomplete penetrance) and for others, the severity of the symptoms may vary from person to person (varying in their expressivity).
Hereditary Cancer screening suggestions for genetic mutation carriers
If a patient tests positive for a gene mutation, our physician will work with them to develop a unique preventive breast cancer screening plan. This may mean more frequent screening options, medications, preventative surgery, or starting annual or semi-annual breast cancer screenings as early as age 25. Test results may be used to inform family members who may also be at risk. For other cancers (i.e. colorectal, ovarian), referrals will be provided to ensure a comprehensive care plan according to the patient’s individual risk.
Benefits of myRisk™ testing
Patients who have a high risk of hereditary cancer will benefit from getting the Myriad myRisk™ Hereditary Cancer Panel because they will be able to develop a better plan to examine, manage or prevent the development of various cancers. While most cancers are sporadic, if a mutation is present, preventive measures can be taken to reduce the likelihood of cancer developing.
What is the cost for myRisk™ testing?
- If the cost for the testing is greater than $375, a Myriad customer service representative will contact you to discuss payment options.
- Patients without insurance or who are underinsured may apply for Myriad’s Financial Assistance Program (MFAP).
Is genetic discrimination a concern?
- HIPAA protects genetic information, and prohibits excluding an individual from group coverage based on genetic information.
- Being BRCA positive is not considered a pre-existing condition.
- Based on GINA – the Genetic Information Non-Discrimination Act, it is illegal to ask about genetic testing prior to providing insurance.
- Myriad will not release test results to anyone, including insurance plans, without the patient's written consent.